Jacques Cartier and his crew, along with natives suffer from a disease called scurvy, due to coldness and lack of health and food. Many casualties. it was only discovered later that it was a piece of boiling white spruce bark that would cure them all.
Giovanni da Verranzo, an Italian navigator, is convinced by Francis I, King of France, to find a cheaper way to trade spices with Asia. He travels through North America, through New Spain and New Found Land, to Asia.