Recent Event Highlights: Genentech Uses Complete Genomics’ Human Genome Sequencing Service to Compare Tumor and Normal Genome in Patient with Non-small Cell Lung Cancer; Results Published in Nature, Sequencing the Genome “Changed Everything”, Response to RavingConservative "Crap Science 4: Human Chimp Genetic Similarity", Neanderthal Genome Sequence Interview with Jim Mullikin, Ph.D., Neandertal Genome Sequenced!!!, The Next Generation of Human Genome Sequencing, and 110 more...
Created by dipity on Nov 25, 2008
Last updated: 01/07/11 at 12:22 PM
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MOUNTAIN VIEW, Calif. -- (BUSINESS WIRE) --
Complete Genomics Inc., a third-generation human genome sequencing
company, today announced that Genentech Inc., a wholly owned member of
the Roche Group (SIX:RO, ROG)(OTCQX:RHHBY), used the
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Freshnews.com
http://www.freshnews.com/news/334063/genentech-uses-complete-genomics%E2%80%99-human-genome-sequencing-service-compare-tumor-and-norm
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Question: What does your research consist
of on a day-to-day
basis?
Michael Wigler: Our lab studies the genome
of organisms and
also the genome of cancer cells.Â
And we work on two kinds of problems: the evolution and outcome
of
cancers, and also on
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Big Think
http://bigthink.com/ideas/19956
Response to video called "Crap Science 4: Human Chimp Genetic Similarity" www.youtube.com RavingConservative's channel: www.youtube.com References: Bhagwati PG and Sternberg PW (2003) The draft genome sequence of the nematode Caeonorhabditis briggsae, companion to C. elegans. Genome Biology 4: 238. Glazko G, Veeramachaneni V, Nei M, and Makalowski W (2005) Eighty Percent of Proteins are Different between Humans and Chimpanzees Gene 346: 215-219. Ijdo JW, Baldini A, Ward DC, Reeders ST, and Wells RA (1991) Origin of human chromosome 2: an ancestral telomere-telomere fusion. Proceedings of the National Academy of Sciences 88: 9051-9055. International Human Genome Sequencing Consortium. 2004. Finishing the euchromatic sequence of the human genome. Nature. 431 (7011): 931-945. Tatsuya Anzai st al., "Comparative Sequencing of Human and Chimpanzee MHC Class | Regions Unveils Insertions/Deletions As the Major Path to Genomic Divergence," Proceedings of the National Academy of Sciences, USA 100 (2003); 7708-13 The Chimpanzee Sequencing and Analysis Consortium. 2005. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature. 437 (7055): 69-87. Some creation links on the topic: www.apologeticspress.org www.icr.org
May 5, 2010 - Interview with Jim Mullikin, Ph.D., Acting Director NIH Intramural Sequence Center. For more information: www.genome.gov
Okay, so it's only a draft sequence... www.sciencemag.org
Illumina CEO Jay T. Flatley on producing new human genome technology.
Genome Sequencing leaves Creationists Unable To Respond. That's what happens when you only got religion and stupid common sense on your side.
Both the public and private efforts to sequence the human genome relied on a technique developed by Fred Sanger (Sanger sequencing) in the late 1970s. V Originally created for DNA Interactive ( www.dnai.org ) TRANSCRIPT As represented by this huge stack of paper, the human genome contains more than three billion nucleotides or DNA letters. The first stage of the public Human Genome Project focused on identifying marker sequences or unique tags (shown here in yellow) at regular intervals throughout this "book of life." Once enough sequences were tagged, various blocks of the genome were allocated to different academic centers for sequencing. To begin the sequencing process, several copies of a section of DNA, represented here as a page of text, are cleaved to produce smaller fragments. Although it looks fairly orderly, this step is "small scale shotgun," which created numerous random fragments. Each fragment is sequenced and then computer programs align the overlap of fragments to build up an entire page. Marker sequences (shown in yellow) help establish the order of pages in the book of life. This methodical process produced huge amounts of data that have been used to virtually reassemble our genome. However there are gaps. Repeat sequences are common in the human genome, so repeats from entirely different chromosome regions may be erroneously joined together. It will take many years to detect mismatches caused by the repeat sequences some regions, especially near the ...
The private project blew the genome apart into pieces of different sizes and used mathematical models and other maps to reconstruct the genome from these pieces. Originally created for DNA Interactive ( www.dnai.org ) TRANSCRIPT Shotgun sequencing is the method that was used by the private genome project. Shotgun sequencing requires multiple copies of the genome, which are effectively blown up into millions of small fragments. Each fragment is then sequenced. The small fragments are assembled using an immense amount of computer power to match overlapping sections. The drawback of this method comes when dealing with repeat sequences. Often there is no way of knowing how long the repeat sequence is; or in which of many different possible positions the fragments overlap. Even the incredibly powerful software used to shotgun sequence the human genome couldn't cope with this. So Celera, the private company which relied on this approach, had to use the public data to fill in the gaps left by the repeats.)
his is a video of Simon Prochnik and Lillian Fritz-Laylin of UC Berkeley and the Department of Energy Joint Genome Institute discussing the Naegleria gruberi genome project. Credit: Massie Ballon/DOE JGI
Johns Hopkins Kimmel Cancer Center scientist Bert Vogelstein, MD, discusses personalized genome sequencing in the Sidney Kimmel Comprehensive Cancer Center's Thought Leaders Video Series
Australian scientists have led an international experiment in mapping out the DNA of Africa's Indigenous peoples, to better understand disease..... Human genomes from Southern African Bushmen and Bantu individuals have been sequenced by a team of scientists seeking a greater understanding of human genetic variation and its effect on human health..... The indigenous hunter-gatherers of southern Africa, often referred to as Bushmen, represent the oldest known lineage of modern man. By sequencing the genomes of four Bushmen and one Bantu representative from Southern Africa, researchers led by Stephan Schuster at Penn State University in the United States and Vanessa Hayes at the University of New South Wales in Australia show that Bushmen have more genetic differences between each other than for example, do a European and Asian. The inclusion in current databases of the Bushman and Bantu genomes sequenced by Stephan Schuster et al. will ensure the inclusion of Southern Africans in medical-research efforts..... "We sequenced the personal genomes of four Bushmen participants who are tribal leaders from their communities and are at least 80 years of age, and from one Bantu participant who is in his late 70s," said Stephan Schuster, a professor at Penn State and a co-leader of the project. The Nature paper reveals the identities of each of these five participants. The other co-leader, Vanessa Hayes of the University of New South Wales, who also is a group leader at Children's ...
Shot this video on a trip up to Cambridge, MA.
www.worldsciencereview.info Genome Sequencing
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...project for endangered species which live on the plateaus, he added. Chinese scientists have contributed to the genome sequencing of rice, silkworm, hen, pig and giant panda. In October 2007, they finished sequencing the first Han Chinese genome. ...
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New Kerala
http://www.newkerala.com/news/fullnews-18566.html
Animated and narrated segments presenting all the essential steps in sequencing a genome. From the NHGRI's Online Education Kit: Understanding the Human Genome Project.
Animated and narrated segments presenting all the essential steps in sequencing a genome. From the NHGRI's Online Education Kit: Understanding the Human Genome Project.
Animated and narrated segments presenting all the essential steps in sequencing a genome. From the NHGRI's Online Education Kit: Understanding the Human Genome Project.
Animated and narrated segments presenting all the essential steps in sequencing a genome. From the NHGRI's Online Education Kit: Understanding the Human Genome Project.
Animated and narrated segments presenting all the essential steps in sequencing a genome. From the NHGRI's Online Education Kit: Understanding the Human Genome Project.
Animated and narrated segments presenting all the essential steps in sequencing a genome. From the NHGRI's Online Education Kit: Understanding the Human Genome Project.
Animated and narrated segments presenting all the essential steps in sequencing a genome. From the NHGRI's Online Education Kit: Understanding the Human Genome Project.
Animated and narrated segments presenting all the essential steps in sequencing a genome. From the NHGRI's Online Education Kit: Understanding the Human Genome Project.
Animated and narrated segments presenting all the essential steps in sequencing a genome. From the NHGRI's Online Education Kit: Understanding the Human Genome Project.
www.sciencedaily.com Added On December 18, 2009 Researchers say they've cracked the genetic codes for melanoma and lung cancer. CNN's Dr. Sanjay Gupta reports. Lung Cancer and Melanoma Laid Bare ScienceDaily (Dec. 17, 2009) — Research teams led by the Wellcome Trust Sanger Institute have generated the first comprehensive analysis of a malignant melanoma and a lung cancer genome. The results, which reveal essentially all the mutations in the genomes, will provide powerful insights into the biology of cancer and lay the foundation for understanding causation and improving prevention, detection and treatment. The ultimate aim will be to generate catalogs for thousands of individual cancer genomes, so that treatments can be directed in the most efficient and cost-effective way. See Also: Health & Medicine * Skin Cancer * Lung Cancer * Breast Cancer * Cancer * Colon Cancer * Brain Tumor Reference * Metastasis * Tumor * Tumor suppressor gene * Lung cancer All cancers are caused by mutations in the DNA of cancer cells which are acquired during a person's lifetime. The studies, of a malignant melanoma and a lung cancer, reveal for the first time essentially all the mutations in the genomes of two cancers. Lung cancer causes around one million deaths worldwide each year: almost all are associated with smoking. The number of mutations found suggest that a typical smoker would acquire one mutation for every 15 cigarettes smoked. Although malignant melanoma comprises only 3% of skin ...
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...them. Can it be said that a typical North Indian 'Indian' has been mapped? We really can't say that. We would have to do genome sequencing of number of people more to be able to note any similarities in gene structures, if any, among Indians. We can't generalise...
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Times of India
http://timesofindia.indiatimes.com/india/Genome-sequencing-can-be-applied-in-clinical-setting/articleshow/5320708.cms
Animated and narrated segments presenting all the essential steps in sequencing a genome. From the NHGRI's Online Education Kit: Understanding the Human Genome Project.
Teams of scientists in the US and Mexico have independently sequenced the most complex plant genome to date. Comparison of two varieties offers insight into the early domestication of corn.
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...and private foundations invest hundreds of millions of dollars in grants to leverage the empirical power of individual genome sequencing. As the cost of sequencing drops, and the tide of genome data rises, data management and analysis are emerging as pressure...
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News-Medical.net
http://www.news-medical.net/news/20091118/Fully-integrated-human-genome-sequencing-and-data-processing-service-launched.aspx
goodnews.ws Horse Genome Sequence Published. Professors Jim Mickelson, PhD, and Stephanie Valberg, DVM, PhD, of the University of Minnesota College of Veterinary Medicine are among the authors of "Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse," to be published in the Nov. 6 issue of the journal Science. The paper will be the first published report of the horse genome sequence. "The sequencing of the equine genome and the publication of this paper in the prestigious journal Science is an important advance for veterinary medicine as well as human health," said Trevor Ames, DVM, MS, Dipl. ACVIM, dean of the College of Veterinary Medicine. "Jim Mickelson, Stephanie Valberg, and their team have achieved a major scientific milestone that will benefit animals and people. We're very proud of them." Sequencing of the horse genome began in 2006, building upon a 10-year collaborative effort known as the Horse Genome Project, in which an international team of scientists built preliminary maps of the horse genome and began using genomics tools to address health issues in horses. Mickelson and Valberg played substantial roles in the project, particularly in building the initial maps of the horse genome and demonstrating that the horse genome maps and DNA sequence tools could be used to identify disease-causing mutations. A team of researchers at the Broad Institute, a research collaboration of the Massachusetts Institute of Technology and Harvard ...
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...Genomes data sets we have been generating with Illumina data in terms of accuracy," says Chad Nusbaum, co-director of the Genome Sequencing and Analysis program at the Broad Institute, in Cambridge, MA. (The 1000 Genomes project is an international effort...
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MIT Technology Review
http://feeds.technologyreview.com/click.phdo?i=5a86ae05e947321d0f0b314eace0fd87
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...demonstrate that the technology of the 454 Sequencing System has effectively replaced Sanger technology for de novo genome sequencing and assembly,” said Christopher McLeod, President and CEO of 454 Life Sciences. “We are extremely excited to continue to work...
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Freshnews.com
http://www.freshnews.com/news/234459/norwegian-team-completes-cod-genome-using-454-sequencing-system
The concept of personalized medical treatment based on a patients DNA is one small step closer to becoming a reality. A Mayo Clinic Cancer Center team in Arizona recently completed its first whole human genome sequencing on a patient suffering from Multiple Myeloma, a cancer of the bone marrow. In a matter of weeks, the Mayo Clinic team, led by hematologist Dr. Keith Stewart and Dr. Jan Egan, a post doctoral fellow, in conjunction with Dr John Carpten and a team of researchers at the Translational Genomics Research Institute (TGen) in downtown Phoenix, completed multiple copies of a whole human genome sequence, capturing an entire snapshot of the patients bone marrow cancer cells through various stages of the disease. We were interested in establishing the reasons why cancer patients become resistant to chemotherapy drugs or alternatively, why they are sensitive to the drugs in the first place, said Dr. Stewart, of the groundbreaking research project which sequenced approximately 60 billion different DNA bases in less than a month after the patients samples had been prepared. This genetic research project was a first for the Mayo Clinic Cancer Center and a key milestone on the way to individualized genome based cancer care. While the practice of genomic sequencing has been around for nearly a decade, Dr. Stewart said this Mayo Clinic led project was particularly unique in that genetic samples were gathered at four different time intervals over the course of about four ...
Complete video at: fora.tv UCSF biostatistics professor Dr. Katherine Pollard describes The Chimp Genome Project, which lists 15 genes associated with human diseases that originate in chimps. While some people have the "new human version" of the gene, others still have the "chimp version." Evidence, she claims, that humans are evolving away from their ancestral version. ----- We are in the midst of a renaissance in the biological sciences, which is spurring the growth of brand new fields like functional and comparative genomics. These new fields are revealing novel insights into evolutionary biology, medicine, developmental biology and many other areas, transforming the way scientists look at life. Join the California Academy of Sciences to learn about genomics, hear about compelling current research, and explore the future of this rapidly advancing field. - California Academy of Sciences Katherine Pollard received her Ph.D. and MA from UC Berkeley Division of Biostatistics under the supervision of Mark van der Laan. Her research at Berkeley included developing computationally intensive statistical methods for analysis of microarray data with applications in cancer biology. After graduating, she did a postdoc at UC Berkeley with Sandrine Dudoit. She developed Bioconductor open source software packages for clustering and multiple hypothesis testing. In 2003, she began a comparative genomics NIH Postdoctoral Fellowship in the labs of David Haussler and Todd Lowe in the ...
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...and existing companies are in the sequencing race, pursuing a range of third-generation technologies. Sequencing the human genome now costs $5,000-50,000, although Church emphasized that none of the efforts so far had been completely successful and no research...
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livemint.com
http://www.livemint.com/2009/10/06202954/IBM-joins-pursuit-of-1000-pe.html
IBM DNA Transistor The Future of Genome Sequencing In an effort to build a nanoscale DNA sequencer, IBM scientists are drilling nano-sized holes in computer-like chips and passing DNA strands through them in order to read the information contained within their genetic code. This research effort is to design a silicon-based DNA Transistor that could help pave the way to easily and quickly read human DNA, generating advancements in health condition diagnosis and treatment. The challenge in the effort is to slow the flow of the DNA through the hole so the reader can accurately decode what is in the DNA. If successful, the project could improve throughput and reduce cost to achieve the vision of personalized genome analysis at a cost of $100 to $1000. In comparison, the first sequencing ever done by the Human Genome Project (HGP) cost $3 billion. A human genome sequencing capability affordable for individuals is the ultimate goal of the DNA sequencing and is commonly referred to as $1000 genome. Ultimately, it can improve the quality of medical care by identifying patients who will gain the greatest benefit from a particular medicine and those who are most at risk of adverse reactions. asmarterplanet.com
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...deliver a quality data set for €500 in 10 years and is one of a number of companies attempting to cut the costs of human genome sequencing. Illumina, which supplies some of GATC’s equipment, is also part of the effort and hopes to reduce the cost to $1,000...
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OutsourcingPharma
http://www.outsourcing-pharma.com/Commercial-Services/GATC-expands-genome-sequencing-services
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...not unlike what shoppers find in grocery stores, researchers found a ... Â >Â read more The 15-Minute Genome: Faster, Cheaper Genome Sequencing On The Way (July 29, 2009) In the race for faster, cheaper ways to read human genomes, Pacific Biosciences is hoping...
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Science Daily
http://www.sciencedaily.com/releases/2009/09/090903111503.htm
The first few times that scientists mapped out all the DNA in a human being in 2001, each effort cost hundreds of millions of dollars and involved more than 250 people. Stephen Quake discusses sequencing his own genome and what he finds.
Bioengineering professor Stephen Quake reports sequencing his own genome for less than $50000 and with a team of just two other people. For full story: med.stanford.edu
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...reactions to peanuts. So, having helped invent an ultra-high-throughput sequencing machine, I used it to sequence my genome. The sequencing itself was amazingly easy - it took a single machine operator two weeks to get tenfold coverage of my genome (it turns...
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MIT Technology Review
http://feeds.technologyreview.com/click.phdo?i=4e910da3352dd4dd4049bc7ae003b327
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...genome sequences, which will revolutionise medical treatment. The cost of sequencing the three billion letters of the human genome was, only a few years ago, priced in the region of many tens of millions of pounds, but Professor Stephen Quake of Stanford University...
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New Zealand Herald
http://www.nzherald.co.nz/science/news/article.cfm?c_id=82&objectid=10590112&ref=rss
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...of millions of dollars and required more than 250 people. Even in 2008, the lowest reported cost of sequencing a human genome was $250,000 and still required almost 200 people. Quake's genome was sequenced using a commercially available, refrigerator-sized...
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KLAS - Las Vegas Now
http://feedproxy.google.com/~r/lasvegasnow/health/~3/91BLrSSbUcM/story.asp
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...95% complete. (This is on par with previous sequencing technology.) While Quake's research is important in what it represents: genome sequencing could become something used by regular health care providers to diagnose genetic predispositions to diseases (or...
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Gizmodo
http://gizmodo.com/5334385/genome-sequencing-gets-999833-price-cut
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...of millions of dollars and required more than 250 people. Even in 2008, the lowest reported cost of sequencing a human genome was $250,000 and still required almost 200 people. Quake's genome was sequenced using a commercially available, refrigerator-sized...
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Medline Plus
http://www.nlm.nih.gov/enter/medlineplus/rss?feed=Todays%20MedlinePlus%20Health%20News&url=http%3A%2F%2Fwww%2Enlm%2Enih%2Egov%2Fmedlineplus%2Fnews%2Ffullstory%5F87954%2Ehtml
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...of millions of dollars and involved more than 250 people. Even last year, when the lowest reported cost was $250,000, genome sequencing still required almost 200 people. In a paper to be published online Aug. 9 by Nature Biotechnology , a Stanford University...
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Fresno Bee
http://www.fresnobee.com/384/story/1588987.html
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...of the 51st Annual Meeting of American Association of Physicists in Medicine, on Monday. Washington, July 28 : Human genome sequencing is expected to become as cheap as 100 dollars per case, and that too at speeds 20,000 times faster than second-generation...
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New Kerala
http://www.newkerala.com/nkfullnews-1-81553.html
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...(GMI) at Seoul National University College of Medicine in Korea, purchased seven additional Illumina Genome AnalyzerIIx sequencing systems, expanding the capacity of their recently established Asian Genome Center to 10 Illumina sequencing systems. “GMI’s decision...
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PR-Inside.com
http://www.pr-inside.com/genomic-medicine-institute-adds-seven-r1401910.htm
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...spend out of pocket for health care last year? NEW YORK (Fortune) -- Price competition is coming to the rarified world of genome sequencing. For $48,000, San Diego-based Illumina (ILMN) will sequence your genome -- in other words, your entire genetic code. Until...
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Bioethics.net
http://www.bioethics.net/News/?id=6684
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