Recent Event Highlights: Pfizer Discontinues Phase 3 Trial of Sutent® in Advanced Hepatocellular Carcinoma - VAdvert Press Center (press release), Pfizer Discontinues Phase 3 Trial of Sutent(R) in Advanced Hepatocellular ... - MarketWatch (press release), Tumors Deficient in a Specific Enzyme Are Sensitive to a New Drug 'ADI-PEG 20', Tumors Deficient in a Specific Enzyme Are Sensitive to a New Drug 'ADI-PEG 20' - PR Newswire (press release), Use of Erlotinib or Gefitinib as Initial Therapy in Advanced NSCLC - Cancer Network, Synta Presents STA-9090 Results at AACR Including Synergy with Avastin(R ... - MarketWatch (press release), and 66 more...
Created by dipity on Apr 15, 2009
Last updated: 10/06/10 at 02:34 PM
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AB Science Brings in €27.5M After Scaling Back its IPOBioWorld OnlineThe compound is undergoing Phase III trials in three indications, namely mastocytosis, gastrointestinal stromal tumor (GIST) and pancreatic cancer. ...
http://news.google.com/news/url?fd=R&sa=T&url=http%3A%2F%2Fwww.bioworld.com%2Fservlet%2Fcom.accumedia.web.Dispatcher%3Fnext%3DbioWorldHeadlines_article%26forceid%3D54342&usg=AFQjCNF_wT7LTuXTkJl1b5R3QJwsoE_P-g
Pfizer Discontinues Phase 3 Trial of Sutent® in Advanced Hepatocellular CarcinomaVAdvert Press Center (press release)Sunitinib is currently approved for both gastrointestinal stromal tumors (GIST) after disease progression on or intolerance to imatinib mesylate, ...and more »
http://news.google.com/news/url?fd=R&sa=T&url=http%3A%2F%2Fwww.vadvert.co.uk%2Fscience%2F1312-pfizer-discontinues-phase-3-trial-of-sutenta%25C2%25AE-in-advanced-hepatocellular-carcinoma.html&usg=AFQjCNFlf1yLw4LnVMRBTQS6Ir1y4lveqQ
SuperGen Inc. Q1 2010 Earnings Call TranscriptSeeking Alpha (blog)Amuvatinib was well-tolerated with no dose limiting toxicities and there was a minor response in a heavily pretreated gastrointestinal stromal tumor or GIST ...and more »
http://news.google.com/news/url?fd=R&sa=T&url=http%3A%2F%2Fseekingalpha.com%2Farticle%2F200952-supergen-inc-q1-2010-earnings-call-transcript&usg=AFQjCNFpz_0g4yX5hSmCargbIFzkyM8PCQ
Pfizer Discontinues Phase 3 Trial of Sutent(R) in Advanced Hepatocellular ...MarketWatch (press release)Sunitinib is currently approved for both gastrointestinal stromal tumors (GIST) after disease progression on or intolerance to imatinib mesylate, ...and more »
http://news.google.com/news/url?fd=R&sa=T&url=http%3A%2F%2Fwww.marketwatch.com%2Fstory%2Fpfizer-discontinues-phase-3-trial-of-sutentr-in-advanced-hepatocellular-carcinoma-2010-04-22%3Freflink%3DMW_news_stmp&usg=AFQjCNGs9p52DfMzOO0M906TajLuAUU4bA
Excerpt
...showed that 88% of 45 different human sarcomas were ASS-deficient. Treatment of two sarcomas, gastrointestinal stromal tumor (GIST) and malignant peripheral nerve sheath tumor (MPNST) with ADI-PEG 20 resulted in inhibition of proliferation. Â Based on analysis...
Source Info
Drugs.com
http://feeds.drugs.com/~r/Drugscom-ClinicalTrials/~3/Oh8oGrV0190/tumors-deficient-specific-enzyme-sensitive-new-adi-peg-20-9239.html
Tumors Deficient in a Specific Enzyme Are Sensitive to a New Drug 'ADI-PEG 20'PR Newswire (press release)Treatment of two sarcomas, gastrointestinal stromal tumor (GIST) and malignant peripheral nerve sheath tumor (MPNST) with ADI-PEG 20 resulted in inhibition ...and more »
http://news.google.com/news/url?fd=R&sa=T&url=http%3A%2F%2Fwww.prnewswire.com%2Fnews-releases%2Ftumors-deficient-in-a-specific-enzyme-are-sensitive-to-a-new-drug-adi-peg-20-91695779.html&usg=AFQjCNFbgby7f5JhA1Hoqy9OgIKxYyECEQ
CytRx: All That Glitters Could Be Gold (NASDAQ:CYTR)TapeBeatGleevec is approved for treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and other cancers. ...and more »
http://news.google.com/news/url?fd=R&sa=T&url=http%3A%2F%2Fwww.tapebeat.com%2F201004206875%2FCompanies-Profiles%2Fcytrx-all-that-glitters-could-be-gold-nasdaqcytr.html&usg=AFQjCNHgE9n2DRMCh_t-0PMWlhlPjJwgnQ
Use of Erlotinib or Gefitinib as Initial Therapy in Advanced NSCLCCancer Network... resistant to these agents 11-13 —a finding analogous to the presence of KIT mutations in imatinib (Gleevec)-sensitive gastrointestinal stromal tumors. ...and more »
http://news.google.com/news/url?fd=R&sa=T&url=http%3A%2F%2Fwww.cancernetwork.com%2Flung-cancer%2Fcontent%2Farticle%2F10165%2F1555985&usg=AFQjCNGzcktIWboMqNx2xuGL9DUxyNnqyg
Synta Presents STA-9090 Results at AACR Including Synergy with Avastin(R ...MarketWatch (press release)Synta is currently conducting Phase 2 trials in non-small cell lung cancer (NSCLC) and gastrointestinal stromal tumors (GIST), two Phase 1/2 clinical trials ...and more »
http://news.google.com/news/url?fd=R&sa=T&url=http%3A%2F%2Fwww.marketwatch.com%2Fstory%2Fsynta-presents-sta-9090-results-at-aacr-including-synergy-with-avastinr-tarcevar-and-taxanes-downregulation-of-hif-1a-inhibition-of-jakstat-2010-04-19%3Freflink%3DMW_news_stmp&usg=AFQjCNHPGFFmVU_tpa_2V5bGc-kXjB7Tdg
TopNews United StatesNew Web Portal Offers 'Wheel of hope' for Those Diagnosed with Rare CancersTopNews United StatesElisa had a wild-kind gastrointestinal stromal tumor (GIST), an unusual type of a rare cancer. She said, "It was really difficult because the oncologist who ...and more »
http://news.google.com/news/url?fd=R&sa=T&url=http%3A%2F%2Ftopnews.us%2Fcontent%2F216810-new-web-portal-offers-wheel-hope-those-diagnosed-rare-cancers&usg=AFQjCNFjybyIS_TDH4z3HmvovPwOsg7dKA
Emily Ellingsen's journey: Young doctor shares her struggle and spirit with ...Victoria Times ColonistThe gist is overall good. My lymph nodes continue to get smaller. Yay! The shadow in my lung is gone. Yay! The only bummer is that I still have involvement ...and more »
http://news.google.com/news/url?fd=R&sa=T&url=http%3A%2F%2Fwww.timescolonist.com%2Fhealth%2FEmily%2BEllingsen%2Bjourney%2BYoung%2Bdoctor%2Bshares%2Bstruggle%2Bspirit%2Bwith%2Bloved%2Bones%2Bonline%2Bdiary%2F2787762%2Fstory.html&usg=AFQjCNFrTWu4BHroVz_UV3Iul6U_fcEpaA
Quick clip of liver metastases after 2 months on Novartis drug Gleevac for treatment of GIST cancer. This represents over 50% reduction in tumor mass volume. Most tumor shrinkage occurs in the 1st year of treatment during this lifetime tumor maintenance regimen.
Imatinib has become the paradigm of targeted drug development. The lessons learned from the clinical trials of imatinib treatment of chronic myeloid leukemia will be reviewed in this section. This will include examples of where imatinib has or has not worked, analysis of target expression versus activation and a discussion of how the success of imatinib can be translated to other malignancies. The section concludes with what this means for research to control or cure cancer in the coming decades. See more at www.ibioseminars.org
Alexa Kelly Aigner was born on Thursday, April 29, 2004. She was the first child and only daughter of Zack and Crys Aigner. She was the light of their life and they loved her so much. In October 2005, when Alexa was 18 months old, she had a small bump at the bottom outside corner of her left eye. It was not worrisome as it would depress when touched but it was not normal. Crys and Zack took Alexa to the pediatrician. He reffered them to an ophthalmolo​gist who reffered them to a plastic surgeon at Children's Medical Center of Dallas. On December 12, 2005 after an MRI, they met a doctor who told them that Alexa's bump was in fact caused by a tumor growing behind her eye and it had metastasize​d from a larger tumor growing on her left adrenal gland. Further testing revealed several other tumors, bone disease, bone marrow disease and a diagnosis of Stage 4 Neuroblastoma. Shortly after Alexa's 2nd birthday, Crys and Zack found out Alexa's cancer had not responded well to the treatment she was on and would need to search for other alternatives. With the help of their doctor, they chose to do an expiremental treatment at the Children's Hospital of Philidelphia. They did a treatment called MIBG-a liquid radiation sent through Alexa's entire body that was ment to find and kill those cancer cells-followed by a single bone marrow transplant. SHe was so radioactive that Crys and Zack couldn't touch her for a few days and had to wear protective covering of clothes and shoes. After ...
Chris is a gastrointestinal stromal tumor survivor. He talks about his participation in a clinical trial, accessing quality care, and finding a counselor to deal with his emotional issues.
Gastrointestinal stromal tumors are rare lesions stemming from connective tissue anywhere along the length of the gut. This video reviews treatment of such a tumor through Laparoscopic Partial Gastrectomy.
Big GIST tumor of the posterior wall ,of the stomach, originating from the lesser curvature,not resectable by laparoscopic approach.
a large enormous tumoral mass solid and fluid mixture ,weight 24.6 kg. histopathology : ovarian well differentiated adenocarcinoma
dorahospital.com http
dorahospital.com http
dorahospital.com http
Servizio trasmesso da Rai 3 sul tumore stromale gastro-intestinale (GIST). Associazione Italiana Gist Info : www.gistonline.it
www.uchospitals.edu The University of Chicago Center for Gastrointestinal Oncology offers specialized treatment for the full range of GI cancers. Learn about the Center and meet some of our physicians. In this video, Mitchell Posner, MD, chief of cancer surgery, provides an overview of the Center, its services, and introduces other members of the physician team. Specialized centers that treat large numbers of patients have experience and protocols that lead to better outcomes. Our gastroenterology and cancer programs have consistently been toped ranked in Illinois and ranked among the very best in the country by US News and World Report. We treat the most challenging conditions, cancers that other hospitals might consider hopeless. Dr. Irv Waxman is a gastroenterologist who specializes in cancer. He works closely with surgeons and oncologists so that our team can offer diagnostic and treatment procedures that are only available at a handful hospitals in the country. We are one of only two hospitals in the country to offer participation in all three phases of clinical trials. Dr. Hedy L. Kindler's latest research allows us to offer clinical trials with the hope of increased survival in advanced pancreatic cancer patients. We feel honored and privileged to care for each patient.
I Tumori Stromali Gastrointestinali (GIST) sono i più frequenti tumori mesenchimali del tratto gastroenterico. Nei paesi sviluppati lincidenza è pari a 10-20 casi per milione di abitanti I GIST sembrano originare dalle cellule interstiziali di Cajal, cellule che funzionano da pacemaker del tratto gastrointestinale regolandone lattività contrattile. Lindagine immunoistochimica gioca un ruolo fondamentale nella diagnosi. Le principali caratteristiche immunoistochimiche dei GIST sono la positività al CD-117 nel 90-95% dei casi, al CD-34 nel 60-70% dei casi e alla SMA nel 30-40% Approssimativamente il 60% dei GIST si localizza a livello gastrico, il 30% nel piccolo intestino, il 5% nellesofago e il 5% nel colon-retto. Nel 2002 Fletcher e coll. hanno proposto una classificazione dei GIST in base alla quale tali tumori possono essere stratificati in 3 differenti categorie di rischio considerando come variabili il numero di mitosi e le dimensioni del tumore. Nel 2006 Miettinen e coll. hanno modificato tale classificazione introducendo come nuova variabile la sede del tumore. Il trattamento standard per i GIST localizzati è la completa resezione chirurgica. Presentiamo un video relativo al trattamento laparoscopico di GIST localizzato a livello della giunzione esofago-gastrica. Lesame istologico ha confermato la diagnosi di GIST a rischio basso, con cellule fusate che allimmunoistochimica è risultato positivo allactina muscolare, al CD-117 e negativo al CD-34 e alla proteina S ...
GIST Cancer Research Fund 2009 Walk for a Cure. This segment is the kickoff with host Dr. Marvell Scott. Introductions to GIST researchers and announcement of raffle winners.
Betrachtung eines aufgeschnittenen Magens mit einer Wucherung Examination of an opened stomach afficted by an excrescence
Please watch this in case you are feeling the same syptoms i did, it was awful but i feel so much better now that i got the help i received,,, Syptoms, stomache throbbing abdominal pain after eating if someone hugs you or touches your stomache and it hurts... I also got to meet rosemary! and her husband who were the sweetest people!
TITLE: Single Port Access (SPA) Proximal Gastric GIST Resection Background: Recent advances in minimally invasive surgery have included methods for reducing the number of incisions for trocar placement. Single Port Access is a novel method allowing the performance of standard laparoscopic procedures through one incision. We have applied Single Port Access (SPA) surgery to procedures of the gastroesophageal (GE) junction through a single skin incision, usually placed within the umbilicus. We report the first Single Port Access resection of a proximal 3cm x 3cm GIST tumor in a patient presenting with an upper gastrointestinal bleed. Methods: Entry into the abdomen was achieved through an 18-mm umbilical incision for placement of a 5-mm trocar for the laparoscope. Skin flaps were subsequently created lateral to the laparoscope for placement of 2 additional trocars for the dissecting instruments. Once the single-port access had been achieved, the dissection of the mass was carried out with the collaboration of the gastroenterologist who performed an upper endoscopy, aiding in the eversion and dissection of the mass and evaluating the gastric resection site intraluminally. The mass was removed successfully, and no intraoperative and postoperative complications occurred. Conclusion: This is our first GIST resection done via a combined NOTES/Single Port Access approach. The principles for laparoscopic dissection and resection of the GIST tumor performed via the single-port ...
Partial Gastric Resection for GIST Tumor by Dr. Fred Tiesenga. Come Visit us at Suburbansurgery.com
In this video, Dr. Suzanne George of Dana-Farber's Center for Sarcoma and Bone Oncology explains how patients with GIST can learn more about enrollment and participation in Project FLAG, a National Institutes of Health-funded study to learn more about hereditary gastrointestinal stromal tumor. Learn more about Project FLAG: www.dana-farber.org
In this video, Dr. George Demetri of Dana-Farber's Center for Sarcoma and Bone Oncology discusses gastrointestinal stromal tumor (GIST) and describes the aims of Project FLAG, a National Institutes of Health-funded study to learn more about a rare type of hereditary GIST. Learn more about Project FLAG: www.dana-farber.org
Reseccion de Gist intestinal. Hallazgo incidental durante una colelap. Dr Luis Poggi
New York TimesAs Pills Treat Cancer, Insurance Lags BehindNew York Times, United StatesThe oral exemplar is Gleevec from Novartis, which since its approval in 2001 has helped turn chronic myeloid leukemia as well as gastrointestinal stromal tumors into manageable diseases for many patients. Douglas Jenson, 75, of Canby, Ore., ...
http://www.nytimes.com/2009/04/15/business/15pill.html?hp
RTT NewsPfizer Discontinues Late-Stage Trial Of Sutent In Advanced Breast ...RTT News, NYSutent is an oral multi-kinase inhibitor, which is currently approved for the treatment of both gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate, and advanced/metastatic renal cell carcinoma. ...Pfizer Stops the Progression of Late Stage Breast Cancer Study E Canada NowPfizer Discontinues One Sunitinib Phase 3 Trial in Advanced Breast ... Business Wire (press release)Pfizer Halts Late-Stage Trial of Sutent for Advanced Breast Cancer EfluxMedia Newsall 70 news articles
http://www.rttnews.com/ArticleView.aspx?Id=902862
Salut i ForçaLa mitad de tumores del estroma gastrointestinal reaparece tras su ...Salut i Força, SpainA pesar de esto, los GIST son potencialmente malignos y algunos pacientes presentan un riesgo significativo de recaÃda y progresión metastásica de la enfermedad, incluso después de una resección completa del tumor. Por este motivo, el doctor Artigas ...
http://www.salut.org/post/67869
Market Wire (press release)The First 'Transplantation Tree of Life' Is Planted at SNU ...Market Wire (press release)Key products of NKL includes Diovan, Exforge, Rasilez (Hypertension treatment), Glivec (Chronic Myelogenous Leukemia and Metastatic Gastrointestinal Stromal Tumor Drug), Sandimmun Neoral (immune system suppressant), Trileptal (Antiepileptic drug), ...
http://www.marketwire.com/press-release/Novartis-Korea-966467.html
Earthtimes (press release)Fondation Ipsen: 5th Colloque Médecine et Recherche of the Cancer ...Earthtimes (press release), UKThe most famous and successful of these drugs is imatinib, approved for the treatment of chronic myelogenous leukemia, gastrointestinal stromal tumor and many other cancers. But there are several other drugs that have also entered the arena, including, ...
http://www.earthtimes.org/articles/show/fondation-ipsen-5th-colloque-meacutedecine,762818.shtml
A 7-year-old girl from Long Island, NY, is on her way home a little more than four weeks after receiving a historic surgery that involved the removal and partial re-implantation of six organs in order to resect an abdominal tumor that otherwise would be inoperable. The 23-hour surgery, which began on Feb. 6, was led by Dr. Tomoaki Kato [(212) 305-5101, 877-LIVER-MD] at NewYork-Presbyterian Morgan Stanley Children's Hospital, and is the first reported pediatric case of its kind. Dr. Kato and his team of seven surgeons and eight other clinicians removed nearly every major organ in the girl's abdominal cavity -- small and large intestines, liver, pancreas, spleen and stomach. Three separate surgical teams worked to remove the tennis ball-sized tumor, which was tangled around vital organs and essential blood vessels. One team worked on the abdominal cavity, while two others prepared the small and large intestines and liver, which were kept healthy outside the body using cold preservation fluid of the kind used in transplantation. Throughout the surgery, the patient's father, a firefighter, was on standby as a transplant donor in case his daughter's liver was too damaged; it was determined to be healthy and viable. The liver, small and large intestines were re-implanted. However, her pancreas, spleen and stomach -- non-vital organs that had been compromised by the tumor -- were unsuitable for re-implantation. While the tumor was rare, Dr. Kato notes that the surgical approach ...
TheMedGuruCancer drug Sutent to be made available in ManchesterTheMedGuru, IndiaIt was given a stamp of approval by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sutent has been in the news because of a ‘postcode lottery’ row after NHS ...
http://www.themedguru.com/articles/cancer_drug_sutent_to_be_made_available_in_manchester-86121330.html
Excerpt
...with NET because these tumors can grow slowly and sometimes produce minor symptoms for quite awhile. As a result, GIST and NET tumors are often found incidentally during tests or treatments for other conditions such as irritable bowel syndrome, Crohns Disease,...
Source Info
TradeArabia
http://www.tradearabia.com/news/newsdetails.asp?Sn=HEAL&artid=158223
A 50 years old male presented with abdominal distension and vague abdominal pain. Was found to have a huge GIST tumor at about 50 cm from the DJ junction, firmly attached to the bowel wall, but no obstruction. The tumor was resected with segmental resection of the adjacent small bowel and primary anastomosis. The tumor was ~ 30x30 cm and 6 kg. The patient had a smooth recovery.
Gastrointestinal stromal tümör (GİST) adı verilen sindirim sistemi tümörleri, sindirim sisteminin destek hücrelerinden kaynaklanmaktadır. GİST genellikle bağırsak duvarında uzun ve yassı kitleler meydana getirir, küçük boyutlu tümörler genellikle bağırsak boşluğuna doğru büyür ve yüzeyinde ülser alanları içerir. Buna karşılık büyük çaplı tümörlerin beslenmeleri yeterli olmadığı için hücre ölümüne ve kanamaya neden olurlar. GİSTler nadir görülen tümörlerdir, bütün sindirim sistemi habis ...
Gleevec receives US approval as first treatment to reduce risk of cancer returning in patients with gastrointestinal stromal tumors Novartis announced today that Gleevec� (imatinib mesylate) tablets* has been approved by the US Food and Drug Administration (FDA) for the post-surgery treatment of adult patients following complete surgical removal of Kit (CD117)-positive gastrointestinal stromal tumors (GIST). Gleevec is now the only post-surgery treatment indicated to delay the return of ...
My dwarf hamster Show Girl has a huge tumor on her chest. It started in February 2008, the growth started to accelerate in December 2008. And yet she's still active like this! She's undergoing surgery in a few days, please wish her success!
www.PreOp.com Medical Malpractice and Patient Education Company Your gynecologist has recommended that you have surgery to remove fibroid tumors from your uterus. But what does that actually mean? The uterus is part of a woman's reproductive system. It's the organ that contains and protects a growing fetus during pregnancy. Medical Malpractice Fibroids are non-cancerous tumors that grow on the inner or outer wall of the uterus. They are quite common - as many as 20% of women over 30 have them. In most cases fibroids do not cause any discomfort and are never detected. Occasionally, however, fibroid tumors can cause problems. Complications from fibroid growth can include Medical Malpractice * Pressure on the urinary system. * Pressure on the intestines. * Interference with the reproductive system * Or infection. Because these tumors can grow to be very large, surgery is usually recommended in order to restore health and to protect the uterus. Medical Malpractice and Patient Education Company
Vea la entrevista completa sólo en www.cedepap.tv Christopher Corless, MD, Ph.D. Diagnóstico del Tumor del Estroma Gastrointestinal (GIST) OncologÃa PatologÃa Jefe de PatologÃa Quirúrgica de la Universidad de Ciencia y Salud de Oregon, EE.UU. -.-.-.-.-.-.-.-.-.-.-.CEDEPAP TV es un canal interactivo de divulgación cientÃfica, capacitación, entrenamiento y orientación en temas cientÃficos. Con el compromiso de promover el desarrollo de la ciencia, se dio forma a esta innovadora forma de ...
Excerpt
...for a new indication – keeping cancer from growing in patients following surgical removal of a gastrointestinal stromal tumor or GIST. GIST is a fairly rare form of cancer that originates in cells found in the wall of the GI tract. These cells, known as interstitial...
Source Info
Drugs.com
http://feeds.drugs.com/~r/Drugscom-NewDrugApprovals/~3/LOdqy4y0wgU/fda-approves-gleevec-prevent-recurrence-rare-gastrointestinal-cancer-1213.html
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