Recent Event Highlights: Different Metastasis Pattern Detected in BRCA-Defective Ovarian Cancer - Medscape, Legislative Update - NCI Cancer Bulletin, Olaparib improved response in BRCA-mutated breast, ovarian cancers - HemOncToday, New therapy 'to slow tumour growth in breast cancer patients' - The Hindu, Revolutionary therapy shows promise for breast cancer patients: Lancet, Breast cancer hope from the pill that shrinks tumours - Daily Mail, and 41 more...
Created by dipity on Jun 24, 2009
Last updated: 11/01/10 at 03:56 AM
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Different Metastasis Pattern Detected in BRCA-Defective Ovarian CancerMedscapeClearly, the importance of this is the potential availability of PARP inhibitors in the future, which in a preliminary manner have been shown to be quite ...
http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNGwP11FIaxsBTk5-wesTGeJZdQfBA&url=http://www.medscape.com/viewarticle/724877
Legislative UpdateNCI Cancer BulletinDr. Daniel Silver of the Dana-Farber Cancer Institute presented “PARP Inhibitors: A Breakthrough in Cancer Therapy?” on June 9. ...
http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNFSOZ4X8-0aOboy349tx-lu7IDRKQ&url=http://www.cancer.gov/ncicancerbulletin/071310/page8
From Simple Grains to Exotic Nanoparticles, Susan G. Komen for the Cure ...Business Wire (press release)Another $5 million to Dana-Farber Cancer Institute in Boston will help scientists do more testing of a promising class of drugs called PARP inhibitors to ...and more »
http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNEPs6rNXYGZBm2NVK0RPCYSvEz9cA&url=http://www.businesswire.com/news/home/20100713006854/en
The HinduOlaparib improved response in BRCA-mutated breast, ovarian cancersHemOncToday... researchers recommend for further research to be conducted before olaparib and other oral PARP inhibitors become available for regular use. ...New drug for inherited breast and ovarian cancers shows promise in early trialsCancer Research UKAstraZeneca's PARP inhibitor olaparib looks promising in Phase IIPharma TimesAstraZeneca's PARP Inhibitor Olaparib Looks Hopeful In Phase IITopNews Arab EmiratesModernMedicineall 158 news articles »
http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNFiyVxLmvTajTCqqCs37Im9ZcL0qw&url=http://www.hemonctoday.com/article.aspx?rid%3D66313
The HinduNew therapy 'to slow tumour growth in breast cancer patients'The HinduAlthough the results look good thus far, Domchek said that more clinical trials will be necessary before olaparib or other PARP inhibitors in development ...
http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNEaZDJdgdX76z-03Q4YFNuzxaYNbA&url=http://beta.thehindu.com/health/medicine-and-research/article502738.ece
Excerpt
...in combination with other agents. And we need to establish definitively that they are better than other drugs," she said. The PARP inhibitors are a transition in the field of cancer drug development. "This is a different way of looking at cancer therapeutics....
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Newstrack India
http://www.newstrackindia.com/newsdetails/167160
Daily MailBreast cancer hope from the pill that shrinks tumoursDaily MailThe scientists say the pill, known as a PARP inhibitor, targets cancer cells caused by faulty BRCA1 and BRCA2 genes without harming the healthy cells. ...
http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNGtEFDqGWZXmb-yMogDclsZ93jd3w&url=http://www.dailymail.co.uk/health/article-1292314/Breast-cancer-hope-pill-shrinks-tumours.html?ito%3Dfeeds-newsxml
Full Text (HTML)Securities Industry News (blog) (subscription)We predicted that small-molecule inhibitors of key BER components should impede the progression of DNA demethylation. Addition of PARP inhibitor ...and more »
http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNGlx52LDwi72elCnkV-QZxp8wx53Q&url=http://www.sciencemag.org/cgi/content/full/329/5987/78
The News For You (blog)Recent Studies Show Breast and Prostate Cancer May Be Caused By Same GeneThe News For You (blog)The research will aid in the creation of a promising new line of medications that will aid against BRCA2-linked cancers, referred to as PARP inhibitors. ...and more »
http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNGUm4MN_GfoHRVSEL_GpCzEuWajCg&url=http://thenewsforyou.com/recent-studies-show-breast-and-prostate-cancer-may-be-caused-by-same-gene/1225/
TopNews United StatesSame Gene Causes Breast and Prostate Cancer, Reports SayTopNews United StatesThe research fabricates on studies of a hopeful new class of drugs for BRCA2-linked breast cancers known as PARP inhibitors. The scientists now deem that ...Mixed results for war on cancerVineland Daily Journalall 27 news articles »
http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNGm5kbjjwpWD2G9hHntSrye94K87A&url=http://topnews.us/content/223052-same-gene-causes-breast-and-prostate-cancer-reports-say
Dr. Michael Danso of Virginia Oncology Associates discusses cutting edge breast cancer treatments. He gave information about PARP inhibitors, and Claudin. Information regarding triple negative breast cancer, BRCA I and BRCA II breast cancer was also discussed.
Dr. Michael Danso of Virginia Oncology Associates was one of the speakers for the program, "The Many Faxes of Breast Cancer." Information regarding triple negative breast cancer, BRCA I and BRCA II, were explored. He also spoke about medications like PARP Inhibitors and Claudin.
Two cancers linked by faulty geneThe Press AssociationThe research builds on studies of a promising new class of drugs for BRCA2 - linked breast cancers known as PARP inhibitors. Scientists now believe the ...PARP inhibitors may be effective in men with prostate cancer due to BRCA2 ...News-Medical.netall 18 news articles »
http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNHzinAQA4PCPbvgxtg_c_IvwC5Afg&url=http://www.google.com/hostednews/ukpress/article/ALeqM5jG2yIoHxXJY3bvMsTNpqkwJV63iw
Excerpt
...discovery builds on research showing that a promising class of new drugs for BRCA2 linked breast cancers – known as PARP inhibitors** – may also be effective in men who have developed prostate cancer due to a BRCA2 alteration. Lead author, Dr Amanda Swain,...
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Cancer Research UK
http://info.cancerresearchuk.org/news/archive/pressrelease/2010-06-24-hereditary-prostate-cancer
An interview with Paula J. Anastasia, RN, MN discussing recurrance in Ovarian Cancer; Importance of Clinical Trials; PARP Inhibitors - ONS 2010
Dr. Hope Rugo talks about a new targeting therapy for breast cancer - PARP inhibitor.
Dr. Monica Morrow talks about the role of the PARP Inhibitor - ASCO 2009
Professor Hilary Calvert has received the Lifetime Achievement Award in the 2009 Excellence in Oncology Awards from the British Oncological Association sponsored by pfizer. Prof Calvert was involved in the development of several oncology drugs in his distinguished career, including carboplatin for ovarian cancer , pemetrexed for Mesothelioma and parp inhibitors. Here he talks about the award and future projects.
Dr Susanne Briest - University of Leipzig, Germany Triple negative breast cancer Dr Susanne Briest from the University of Leipzig, Germany, interviewed at ECCO 15 - ESMO 34, Berlin, Sept 2009. Features of triple negative breast cancer and various cancers within the triple negative grouping. PARP inhibitors. Grouping tumours by similarity to BRCA 1- 'BRCAness'. Multidisciplinary teams. Speaking to managing editor Prof Gordon McVie.
sorry i went over time limit so here is the wrap up. Please comment, ask questions.
Started taking AZD2281, a PARP Inhibitor developed to keep Advanced/Recurrance of Ovarian Cancer patients with BRCA1 +, in remission!
Dec. 15, 2009 6 cycles Chemo completed. Hoping for REMISSION. Preparing for PARP1 Study.
www.medpagetoday.com SAN ANTONIO -- Treatment with a drug that inhibits DNA repair in cancer cells improved breast cancer patients' survival by almost 60% when added to conventional chemotherapy, according to results from an ongoing study.
Joyce OShaughnessy, MD, Baylor-Charles A. Sammons Cancer Center, Dallas, Texas, speaking at ASCO 2009: PARP Inhibitor BS-201 Plus Chemotherapy May Offer New Treatment Option for Triple-Negative Breast Cancer: A randomized Phase II study, featured in ASCOs plenary session, shows that women with metastatic triple-negative breast cancer who received the investigationalPARP inhibitor BSI-201, in combination with conventional chemotherapy, lived significantly longer and experienced significantly better progression-free survival than women who received standard chemotherapy alone.
Dr. Andrew Tutt - Breakthrough Breast Cancer Research Unit, Kings College London, UK A study reports that women with BRCA deficient advanced breast cancer experienced tumour shrinkage after receiving the PARP inhibitor olaparib as a single agent.
Excerpt
...be effective for treatment of any tumour with reasonably low levels of oxygen - especially the most aggressive tumours." PARP inhibitors block PARP, a protein which is part of DNA's 'emergency repair kit' in cells - it prevents mistakes being passed on to...
Source Info
Cancer Research UK
http://info.cancerresearchuk.org/news/archive/pressrelease/2009-10-14-experimental-drug-may-work-widely
Excerpt
...aggressive tumours often have the lowest oxygen levels. They found that cancer cells with low oxygen levels are sensitive to PARP inhibitors - an experimental group of cancer drugs. The research suggests the drug could be a powerful therapy used on its own...
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Medical News Today
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http://www.medicalnewstoday.com/articles/166733.php
Dr Ester Hammond, from the Gray Institute for Radiation Oncology and Biology talks about her research showing that PARP inhibitor drugs could be used to treat many different cancers. Presented at the 2009 NCRI Cancer Conference
Dr Hammond talks about her research showing that PARP inhibitor drugs could be used to treat cancers that have low levels of oxygen (hypoxia)
Experimental breast cancer treatments include hormonal therapies that eliminate or counteract estrogen, and other treatments involve the use of monoclonal antibodies. Learn about PARP inhibitors as a part of experimental breast cancer treatments with information from an oncologist in this free video on treatments for breast cancer. Expert: Grace Wang, MD Contact: www.komenmiaftl.org Bio: Dr. Grace Wang, MD, is an oncologist and hematologist for Advanced Medical Specialties. Filmmaker: Paul Muller
Thank you so much to everyone (believers and non-believers) for your prayers and the responses on alternative cancer treatments. So far I have the following: STOP EATING REFINED WHITE SUGAR 1) Laetrile, B17, amygdalin, apricot seeds 2) Hemp Oil 3) DCA 4) Chiropractic care spine alignment 5) Radically change diet to God foods 6) PARP inhibitor 7) Essiac tea 8) MGN-3 I am a Christian. I believe in the teachings of Jesus Christ. If you are also a Christian, please save your breath before preaching to me about my cussing and actions. I am accountable to God and not you. As a matter of fact, I despise mainstream modern religion. Our country is going to hell and you want to make videos on sanctimonious Christians. Ok, whatever. Do as you please, just don't send it to me. I have found better company in bars and pool halls than in some mainstream churches. DEATH TO THE NWO. Obama, show us the birth certificate.
Looking for advice on alternative cancer treatments (B17, Laetrile, Amygdalin, Chiropractic, hemp oil) I am specifically looking for laetrile therapy doctors in the Dallas area. Or even a place to purchase laetrile in the United States. If you have been down this road or know someone who has, I would love to hear from you and learn what you have to share. I doubt my wife will give up her radiation and chemotherapy treatments because she is not as anti-establishment as I am and in such a life and death situation a person will hold strongly to their core belief systems. However she may be willing to take some laetrile pills in addition to the mainstream treatments. The challenge I have is that I do not know any doctors that offer alternative laetrile (or other) cancer treatments in the Dallas area. I am making this video public in the event someone has contacts in the Dallas area and I will continue to do my own research as well. Thank you so much to everyone for your prayers and the responses on alternative cancer treatments. So far I have the following: 1) Laetrile, B17, amygdalin 2) Hemp Oil 3) DCA 4) Chiropractic care spine alignment 5) Radically change diet to God foods 6) PARP inhibitor
NBC Evening News 6/24 - PARP Inhibitors a new cancer treatment
Modern MedicineOlaparib May Benefit BRCA Mutation Carriers PARP inhibitor shows ...Modern Medicine, NJThey observed that olaparib effectively inhibited PARP, and found that it had objective antitumor activity only in mutation carriers. "Readers may be surprised by the editors' decision to publish a small early-stage trial, but this trial not only ...New cancer drug 'shows promise' BBC Newsall 24 news articles
http://www.modernmedicine.com/modernmedicine/Pathology/Olaparib-May-Benefit-iBRCAi-Mutation-Carriers/ArticleNewsFeed/Article/detail/606351?contextCategoryId=40144
Nhatky.inProtein Summons Help DNA Repair Teams Fix Cancer-Causing DefectsNhatky.in, IndiaPeng said that the findings hold potential to treat cancer cells lacking BRIT1 with PARP inhibitors-drugs that specifically kill HR-deficient cancer cells. The study has been published online in Nature Cell Biology. (ANI)
http://www.nhatky.in/protein-summons-help-dna-repair-teams-fix-cancer-causing-defects-12338529
العراق للجميعأدوية جديدة لمكافحة سرطان الثديالعراق للجميع, Iraqبفضل تعاون بين فرق الباحثين، بايطاليا(معهد السرطانات بمدينة ميلانو) وبريطانيا(كينغز كوليدج بلندن) وأميركا(معهد الأبحاث السرطانية بدالاس)، يوجد اليوم دواء في مرحلته الاختبارية يدعى "مثبط بارب" (Parp-inhibitor). يذكر أن "بارب" مختصر مفيد للإشارة الى ...
http://www.iraq4allnews.dk/new/ShowNews.php?cat=18&id=21870
Excerpt
...inhibitors affect cancer cells by altering their ability to replicate DNA and grow. In theory and in animal models, they work syngergistically with more traditional chemotherapy agents, since PARP inhibition should make chemotherapy (or any drug which damages...
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Gerson Lehrman Group
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http://feedproxy.google.com/~r/GLGNews/Healthcare/~3/WlSB3WZt2tA/PARP-Inhibitor-shows-very-encouraging-results-in-metastatic-breast-cancer-39982.html
Excerpt
...of drugs may have potential for the treatment of two types of breast cancer that are notoriously difficult to treat. Called PARP inhibitors, the drugs block the ability of damaged cells to repair themselves, causing cancer cells to die off or become more susceptible...
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WebMD
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http://www.webmd.com/breast-cancer/news/20090602/new-drug-for-hard-to-treat-breast-cancer?src=RSS_PUBLIC
WVNS-TVHealthWatch for June 1, 2009WVNS-TV, WVThey've found some early success with a drug known as a PARP inhibitor. While not a cure, the treatment cuts down on DNA damage which is one of the causes of cancer. Seniors appear to stay healthier when they live with a spouse. ...
http://www.wvnstv.com/story.cfm?func=viewstory&storyid=60130&catid=36
U.S. News & World ReportHealth Buzz: Promising Breast Cancer Drugs and Other Health NewsU.S. News & World Report, DCExperimental drugs called PARP inhibitors have been shown to shrink tumors in breast cancers that don't respond well to treatment, Reuters reports. One drug under development by a part of Sanofi-Aventis SA increased the median survival rate from 5.7 ...Novel anticancer strategy targets DNA repair Nature.com (subscription)New Breast Cancer Drugs Show Amazing Promise dBTechnoSanofi has winning cancer drug, but short patent ReuterseFitnessNow - AFPall 135 news articles
http://health.usnews.com/articles/health/2009/06/01/health-buzz-promising-breast-cancer-drugs-and-other-health-news.html
Excerpt
...while Genentech will pursue the additional indication in the U.S. Another hot topic today is a new class of drug called PARP inhibitors. The compounds work by "obstructing the ability of cells damaged by chemotherapy or through genetic mutations to repair...
Source Info
FiercePharma
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http://www.fiercepharma.com/story/asco-hightlights-herceptin-parp-inhibitors/2009-06-01?utm_medium=rss&utm_source=rss&cmp-id=OTC-RSS-FP0
BRCA genes / Â lifestyle factors and PARP inhibitors Response by: Mary-Claire King, PhD (from the audience) American Cancer Society Professor, Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA Alan Ashworth, BSc, PhD, FRS (from the audience) Professor, Molecular Biology and Director, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK ... none
Excerpt
...is enrolled in a clinical trial at Boston's Dana Farber Cancer Institute to see if Poly ADP-Robose Polymerase pills, or PARP inhibitors, might stave off ovarian or breast cancer in women with the BRCA 1 or 2 genetic mutation even more effectively than chemotherapy,...
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Boston Channel.com
http://feedproxy.google.com/~r/Thebostonchannel/local/~3/sCHAjRK6SuM/detail.html
just flashing fun music country song by: Sayan
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